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Equihaler

Breathe Easy

An innovation in the management of severe equine asthma.

What Makes ASERVO EQUIHALER unique

Designed to consistently deliver ciclesonide

  • Soft Mist™ Technology delivers medication in a slow-moving mist1

  • Prodrug activated in the airway epithelium2

  • Activated prodrug has 12 times greater glucocorticoid receptor affinity than dexamethasone2

  • No statistically significant decrease in serum cortisol3,4

  • Accepted by >93% of horses5

  • Proven safety and efficacy under controlled and field conditions in over 600 horses*3,5,6

* Treated with ASERVO EQUIHALER or placebo.

In a large clinical field study, the most common adverse reactions reported were coughing, nasal discharge, sneezing, and nasal irritation/bleeding.

The questionnaire linked below helps to review a horse's respiratory health signs, health history and other important topics.

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What makes ASERVO EQUIHALER unique

A combination of a novel glucocorticoid (ciclesonide) and advanced inhalation technology (Soft Mist™ Inhaler) designed specifically for horses.

Ciclesonide

A novel glucocorticoid that is activated in the lower airway into the potent anti- inflammatory des-ciclesonide.

Soft MistTM Technology

The Soft Mist™ Inhaler provides high fine-particle fraction for deep peripheral lung deposition, low velocity stream for easy inhalation and predetermined dosing for accurate delivery.

Made for Horses

The nostril adapter fits inside the left nostril of the horse, while the BreathView® indicator allows the user to time the generation of the mist with the beginning of inhalation. The inhaler is ergonomically designed for left-hand use, allowing the right hand to remain free to control the horse.

Administration of glucocorticoids may worsen existing bacterial, fungal, or viral infection and may induce the first stage of parturition. Glucocorticoids should be used with caution in horses at a higher risk for laminitis. Do not use in horses with known hypersensitivity to ciclesonide or glucocorticoids.

The activated prodrug is 12x as potent compared to dexamethasone2

Ciclesonide
Ciclesonide is
an active prodrug
Activated to
des-ciclesonide
in the airway
Des-ciclesonide binds
to the glucocorticoid
receptors in the lungs

No statistically significant effect on serum cortisol3,4

A decrease in serum cortisol level is a marker of systemic exposure to administered glucocorticoids and this decrease may reflect the potential for an increased risk of adverse consequences.7

Administration of glucocorticoids may worsen existing bacterial, fungal, or viral infection. Secondary infections should be ruled out before prescribing ASERVO EQUIHALER. Inhaled glucocorticoids should be used with caution, if at all, in horses with active infection of the respiratory tract.

The Soft Mist™ Technology advantage

HIGH FINE- PARTICLE FRACTION

>90% of particles in ASERVO EQUIHALER are <5µm in diameter

Optimal size for deep peripheral lung deposition

LOW-VELOCITY STREAM

The mist in ASERVO EQUIHALER is released at low-velocity (0.8m/sec) for longer duration (>1 sec) 8

Easy to inhale
Validated in horses with severe equine asthma 3

PROPELLANT- FREE

Mechanical energy of the compressed spring generates the Soft Mist™

Propellant-free inhaler has lower carbon footprint compared to pMDI 9

DOSING ACCURACY

Each actuation consistently delivers a predetermined dose

Consider appropriate wash out times prior to administering NSAIDs or additional glucocorticoids.

Softmist

Soft Mist™ Technology = small particle size × low velocity

Smaller, respirable particles (<5 microns) administered at low velocity travel with inhaled air deep into peripheral lung.10

How the mist is made

Designed for horses

Not for use in humans. Keep this and all medications out of the reach of children. In case of accidental inhalation, seek medical advice immediately.

Horse

Easy to use

  • Nostril adapter

  • BreathView® breath indicator

  • Single use

  • Single-hand maneuver

  • Simple treatment protocol

  • Fill indicator

Designed for horses

  • Snug fit in the left nostril serves as reservoir for the drug

  • Easy timing with beginning of inhalation

  • Minimizes risk for cross-contamination between horses

  • Second hand is free to aid in handling the horse

  • One dose fits all

ASERVO® EQUIHALER® (ciclesonide inhalation spray)

  • Soft Mist™ is easily inhaled into the lower airway1

  • Local drug activity deep within the lung2

  • Proven safe3,4

Device
  • Prodrug reduces inflammation to decrease airway obstruction2

  • Accepted by >93% of horses5

  • Studied in over 600 horses under controlled and field conditions3,5,6

    *Treated with ASERVO EQUIHALER or placebo.

Inhaled glucocorticoids should be used with caution, if at all, in horses with active infection of the respiratory tract. If clinical signs do not improve or worsen despite administration of ASERVO EQUIHALER, the prescriber should consider additional diagnostic evaluation.

IMPORTANT SAFETY INFORMATION: ASERVO EQUIHALER has not been evaluated in pregnant or lactating mares. In a large clinical field study, the most common adverse reactions reported were coughing, nasal discharge, sneezing and nasal irritation/bleeding. Administration of glucocorticoids may worsen existing bacterial, fungal, or viral infection and may induce the first stage of parturition. Glucocorticoids should be used with caution in horses at a higher risk for laminitis. Not for use in humans. Keep this and all medications out of the reach of children. In case of accidental inhalation, seek medical advice immediately.

INFORMATION FOR HORSE OWNERS: After veterinary consultation, please read and understand the entire contents of the user manual for instructions regarding proper handling and use of ASERVO EQUIHALER.

IMPORTANT SAFETY INFORMATION:
ASERVO EQUIHALER has not been evaluated in pregnant or lactating mares. In a large clinical field study, the most common adverse reactions reported were coughing, nasal discharge, sneezing, and nasal irritation/bleeding. Administration of corticosteroids may worsen existing bacterial, fungal, or viral infection and may induce the first stage of parturition. Glucocorticoids should be used with caution in horses at a higher risk for laminitis. Not for use in humans. Keep this and all medications out of the reach of children.

Storage Information:
Store at 15-30°C (59-86°F) with excursions permitted up to 40°C (104°F). Protect from freezing. Use within 12 days of activation.